Azor medication5/1/2023 QBRELIS should be started under close medical supervision and followed closely for the first 2 weeks of treatment and whenever the dose of QBRELIS and/or a diuretic is increased. Hypotension: QBRELIS can cause symptomatic hypotension, sometimes complicated by oliguria, progressive azotemia, acute renal failure, or death. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on QBRELIS. Patients whose renal function may depend in part on the activity of the RAS (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, post-MI or volume depletion) may be at particular risk of developing acute renal failure on QBRELIS. Changes in renal function, including acute renal failure, can be caused by drugs that inhibit the renin-angiotensin system (RAS). Impaired Renal Function: Monitor renal function in patients treated with QBRELIS. Anaphylactoid reactions have also been reported in patients undergoing low-density lipoprotein apheresis with dextran sulfate absorption and in patients undergoing desensitizing treatment with hymenoptera venom. In these patients, consideration should be given to using a different type of dialysis membrane or a different class of antihypertensive agent. Symptoms have not been relieved by antihistamines in these situations. In such patients, dialysis must be stopped immediately, and aggressive therapy for anaphylactoid reactions must be initiated. Discontinue QBRELIS and obtain appropriate therapy.Īnaphylactoid Reactions: Sudden and potentially life-threatening anaphylactoid reactions have occurred in some patients dialyzed with high-flux membranes treated concomitantly with an ACE inhibitor. Intestinal angioedema has been reported with ACE inhibitors. ACE inhibitors have been associated with a higher rate of angioedema in Black than non-Black patients. Patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor. Head and Neck Angioedema: Angioedema of the face, extremities, lips, tongue, glottis, and/or larynx, including some fatal reactions, have occurred in patients treated with ACE inhibitors, including QBRELIS, at any time during treatment. Do not administer QBRELIS within 36 hours of switching to or from sacubitril/valsartan. QBRELIS is contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). QBRELIS is contraindicated in patients with hereditary or idiopathic angioedema.ĭo not co-administer aliskiren with Qbrelis in patients with diabetes. QBRELIS is contraindicated in patients who are hypersensitive to lisinopril or any component of QBRELIS, or in patients with a history of hypersensitivity related to previous ACE inhibitor treatment. ADDITIONAL IMPORTANT SAFETY INFORMATION: Contraindications:
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